Administrative support: Brandi Carr and Kerensa Jackson-Burton.
Jun Huang received his MS in chemical engineering and PhD in bioengineering at the Georgia Institute of Technology. He did his postdoctoral research in immunology at Stanford University.
Huang started his academic career as a faculty member in molecular engineering at the University of Chicago in 2015. He is a recipient of the American Cancer Society Scholar Award, Lynn Sage Research Award, NIH New Innovator Award, NSF Career Award, the Cancer Research Foundation Young Investigator Award, CBC Catalyst Award, and the NIH Pathway to Independence Award.
The Huang laboratory studies human immunology and immunotherapy at the single-cell level, with foci in T cell recognition and differentiation.
Huang Lab develops mRNA-based immunotherapies and adoptive cell therapies for human cancer, infectious diseases, and autoimmune disorders.
Stable, small, specific, low-valency quantum dots for single-molecule imaging
Jungmin Lee, Xinyi Feng, Ou Chen, Moungi G Bawendi, Jun Huang. Stable, small, specific, low-valency quantum dots for single-molecule imaging. Nanoscale. 2018. Vol. 10.
CD8+ T cells and NK cells: parallel and complementary soldiers of immunotherapy
Jillian Rosenberg, Jun Huang. CD8+ T cells and NK cells: parallel and complementary soldiers of immunotherapy. Current Opinion in Chemical Engineering. 2018. Vol. 19, Pg. 9-20.
The receptor repertoire and functional profile of follicular T cells in HIV-infected lymph nodes
Ben S. Wendel, Daniel Del Alcazar, Chenfeng He, Perla M. Del Río-Estrada, Benjamas Aiamkitsumrit, Yuria Ablanedo-Terrazas, Stefany M. Hernandez, Ke-Yue Ma, Michael Betts, Laura Pulido, Jun Huang, Phyllis A. Gimotty, Gustavo Reyes-Terán, Ning Jiang, Laura F. Su. The receptor repertoire and functional profile of follicular T cells in HIV-infected lymph nodes. Science Immunology. 2018.
Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells
Yunlong Zhao, Devin L. Harrison, Yuran Song, Jie Ji, Jun Huang, Enfu Hui. Publications. Cell Reports. 2018. Vol. 24, Pg. p379–390.e6.
A myeloperoxidase-responsive and biodegradable luminescent material for real-time imaging of inflam.
Jiawei Guo, Hui Tao, Yin Dou, Lanlan Li, Xiaoqiu Xu, Qixiong Zhang, Juan Cheng, Songling Han, Jun Huang, Xiaodong Li, Xiaohui Li, Jianxiang Zhang. A myeloperoxidase-responsive and biodegradable luminescent material for real-time imaging of inflam.. Materials Today. 2017. Vol. 20, Pg. 493-500.
Cathepsin-Mediated Cleavage of Peptides from Peptide Amphiphiles Leads to Enhanced Intracellular Pep
Handan Acar, Ravand Samaeekia, Mathew R Schnorenberg, Dibyendu K Sasmal, Jun Huang, Matthew V Tirrell, James L LaBelle. Cathepsin-Mediated Cleavage of Peptides from Peptide Amphiphiles Leads to Enhanced Intracellular Pep. Bioconjugate chemistry. 2017. Vol. 28, Pg. 2316-2326.
T cell co-stimulatory receptor CD28 is a primary target for PD-1–mediated inhibition
Enfu Hui, Jeanne Cheung, Jing Zhu, Xiaolei Su, Marcus J Taylor, Heidi A Wallweber, Dibyendu K Sasmal, Jun Huang, Jeong M Kim, Ira Mellman, Ronald D Vale. T cell co-stimulatory receptor CD28 is a primary target for PD-1–mediated inhibition. Science. 2017.
Single-molecule fluorescence resonance energy transfer in molecular biology
Dibyendu K Sasmal, Laura E Pulido, Shan Kasal, Jun Huang. Single-molecule fluorescence resonance energy transfer in molecular biology. Nanoscale. 2016. Vol. 8, Pg. 19928-19944.
Detection, phenotyping and quantification of antigen-specific T cells using a peptide-MHC dodecamer
J. Huang, X. Zeng, N. Sigal, P. J. Lund, L.F. Su, H. Huang, Chien, S. and M. M. Davis. Detection, phenotyping and quantification of antigen-specific T cells using a peptide-MHC dodecamer. Proceedings of the National Academy of Sciences. 2016.
Gamma delta T cells recognize haptens and mount a hapten-specific response
Xun Zeng, Christina Meyer, Jun Huang, Evan W Newell, Brian A Kidd, Yu-Ling Wei, Yueh-hsiu Chien. Gamma delta T cells recognize haptens and mount a hapten-specific response. Elife. 2014. Vol. 3, Pg. e03609.